Determinants of bone health in elderly Japanese men: study design and key findings of the Fujiwara-kyo Osteoporosis Risk in Men (FORMEN) cohort study

BACKGROUND@#The Fujiwara-kyo Osteoporosis Risk in Men (FORMEN) study was launched to investigate risk factors for osteoporotic fractures, interactions of osteoporosis with other non-communicable chronic diseases, and effects of fracture on QOL and mortality.@*METHODS@#FORMEN baseline study participants (in 2007 and 2008) included 2012 community-dwelling men (aged 65-93 years) in Nara prefecture, Japan. Clinical follow-up surveys were conducted 5 and 10 years after the baseline survey, and 1539 and 906 men completed them, respectively. Supplemental mail, telephone, and visit surveys were conducted with non-participants to obtain outcome information. Survival and fracture outcomes were determined for 2006 men, with 566 deaths identified and 1233 men remaining in the cohort at 10-year follow-up.@*COMMENTS@#The baseline survey covered a wide range of bone health-related indices including bone mineral density, trabecular microarchitecture assessment, vertebral imaging for detecting vertebral fractures, and biochemical markers of bone turnover, as well as comprehensive geriatric assessment items. Follow-up surveys were conducted to obtain outcomes including osteoporotic fracture, cardiovascular diseases, initiation of long-term care, and mortality. A complete list of publications relating to the FORMEN study can be found at https://www.med.kindai.ac.jp/pubheal/FORMEN/Publications.html .

Associations between trunk-to-peripheral fat ratio and cardiometabolic risk factors in elderly Japanese men: baseline data from the Fujiwara-kyo Osteoporosis Risk in Men (FORMEN) study

BACKGROUND@#Body mass-independent parameters might be more appropriate for assessing cardiometabolic abnormalities than weight-dependent indices in Asians who have relatively high visceral adiposity but low body fat. Dual-energy X-ray absorptiometry (DXA)-measured trunk-to-peripheral fat ratio is one such body mass-independent index. However, there are no reports on relationships between DXA-measured regional fat ratio and cardiometabolic risk factors targeting elderly Asian men.@*METHODS@#We analyzed cross-sectional data of 597 elderly men who participated in the baseline survey of the Fujiwara-kyo Osteoporosis Risk in Men (FORMEN) study, a community-based single-center prospective cohort study conducted in Japan. Whole-body fat and regional fat were measured with a DXA scanner. Trunk-to-appendicular fat ratio (TAR) was calculated as trunk fat divided by appendicular fat (sum of arm and leg fat), and trunk-to-leg fat ratio (TLR) as trunk fat divided by leg fat.@*RESULTS@#Both TAR and TLR in the group of men who used ≥ 1 medication for hypertension, dyslipidemia, or diabetes ("user group"; N = 347) were significantly larger than those who did not use such medication ("non-user group"; N = 250) (P < 0.05). After adjusting for potential confounding factors including whole-body fat, both TAR and TLR were significantly associated with low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglyceride, fasting serum insulin, and the insulin resistance index in the non-user group and non-overweight men in the non-user group (N = 199).@*CONCLUSION@#The trunk-to-peripheral fat ratio was associated with cardiometabolic risk factors independently of whole-body fat mass. Parameters of the fat ratio may be useful for assessing cardiometabolic risk factors, particularly in underweight to normal-weight populations.

Does the Hot Spring Contribute to the Active Life Expectancy?-The 3 years follow-up survey in the J town which commenced health promotion facilities using hot spring- / 日本温泉気候物理医学会雑誌

In the town which commenced health promotion facilities using hot spring in May, 2000, how the utilization frequency influences afterwards health status and active life expectancy, was investigated by the follow-up study.<br>The research subjects were all inhabitants aged 40 or more years living in J town with about 10, 000 inhabitants in Toyama Prefecture, Japan. The cooperation request of the survey was carried out to women's association, when the survey was performed in December, 2000.<br>With regard to the entry survey, the answers of 5, 812 (95.0%)of the 6, 117 registered inhabitants were collected. They were served to the follow-up survey on (1) death, (2) bone fracture, (3) cerebral apoplexy, (4) senile dementia, (5) welfare facilities entrance, (6) long term admission beyond 6 months, (7) bed bound, (8) diabetes mellitus from April, 2001 to March, 2004. The sex-age matched control was randomly selected from the inhabitants participated in the entry survey for case-control study.<br>As the result, the occurrence rates of (1) death and (2) bone fracture were significantly lower in the group with twice or more utilization of the hot spring per year compared with the group utilizing once or less per year, and (3) cerebral apoplexy showed the slightly significant relationship, even after adjusting with exercise habit and WHO-QOL of confounding factors. The other events were not significantly associated with frequency of hot spring utilization.<br>It has been indicated that health promotion facilities using hot spring could contribute to active life expectancy via health and welfare promotion.

The Relationship between Spa Visit and Quality of Life-Investigating as a confounding factor to health effects of spa- / 日本温泉気候物理医学会雑誌

Spa could have direct effects for physical and mental health but also non-daily pleasure with a visit to spa itself and surroundings. Therefore, the visit should be strongly related with quality of life (QOL) as well as general health status. First of all, this study was conducted to clarify these relationships. Secondly, the QOL was investigated as a confounding factor to health effects of spa. Subjects of this study are about all 6, 000 citizens older than 40 years of age living in Japanese J-town. Self-administrated questionnaires were distributed to the subjects at once and collected for the analysis (Response rate; 94.5%). With regard to the spa visit, (1) no visit at all recently in two or three years, (2) once a year, (3) twice or three times a year and (4) once a month, (5) twice or three times a month were classified.<br>With regard to QOL (Quality of Life), a questionnaire of WHO-QOL was used. The present study demonstrated the visitors to spa have significantly higher WHO-QOL for each subcategory; physical health, psychological status, social relationship, and environment status compared with non-visitors. Therefore, the visitors have had higher total scores of WHO-QOL compared with non-visters. With regard to past history of fracture, the visitors have had significantly lower it's prevalence compared with non-visitors. However, the significance of prevalence was cancelled in adjusting the WHO-QOL. WHO-QOL relating to the frequency of spa visit as well as the prevalence of fracture was identified as a confounding factor to health effects of spa.

Demands and Supplies of Manipulative Therapies for Muscle-Skeletal Complaints in Japan / 日本温泉気候物理医学会雑誌

The demand-supply status of manipulative therapies for muscle-skeletal complaints in Japan were observed and analyzed using data published in 1995.<br>The results were as follows.<br>1. In Japan, the average prevalence rate was 69.6 for shoulder stiffness, 71.8 for lower back pain, and 46.1 for joint pain as of 1995 (per 1, 000 population). The prevalence rates were higher in women than in men and higher in prefectures located in the west part than in the east part of Japan. Differences in prevalence rates of the three complaints of several times were seen among the 46 prefectures.<br>2. On average, there were 66.6 massagers/chiropractors, 45.0 acupuncturists, 44.0 moxibustionists, and 20.2 bonesetters as of 1995 in Japan (per 100, 000 population). These numbers were higher in prefectures located in the west part than in the east part of Japan.<br>3. The rate of outpatients attending massagers, chiropractors, acupuncturists, moxibustionists, or bonesetters as of 1995 in Japan was 23.7per 1, 000 population. The rate of outpatients was higher in women than in men and higher in prefectures located in the west part than in the east part of Japan.<br>4. The rate of outpatients in each prefecture showed a significant correlation with the prevalence rates of muscle-skeletal complaints (r=0.51 for shoulder stiffness, r=0.44 for low back pain, and r=0.68 for joint pain) and with the numbers of manipulative therapists (r=0.31 for massagers/chiropractors, r=0.36 for acupuncturists, r=0.35 for moxibustionists, and r=0.57 for bonesetters).<br>5. Based on multiple correlation analysis showing the correlation of the rate of outpatients with the number of therapists, the prevalence rate of shoulder stiffness (partial correlation coefficient: PCC=0.61) and the number of bonesetters (PCC=0.65) showed significant correlation with the number of outpatients visiting therapists, and its multiple correlation coefficient was 0.76 (<0.001).